From the South, from New York City, Long Island and points south:

* Take New York State Thruway (Interstate 87) North to Kingston (Exit 19). * Follow Route 28 West for 28 miles to Shandaken, then take Rte 42 North, 11 miles to Lexington. * Take a left and follow Route 23A West for 7 miles to Prattsville.

There is a second alternative, with a steep winding road to the mountaintop and a nice view of Kaaterskill Falls along the way:
* Exit NY State Thruway at Saugerties (Exit 20). Follow Rte 32 North to Palenville. * Then take Rte 23 West though Haines Falls, Tannersville, Hunter, to Prattsville.

From the North, Albany, Boston, Canada
* Take New York State Thruway (Interstate 87) South to Catskill (Exit 21). * Follow Route 23 West through Cairo, Windham, Ashland, to Prattsville.

From the West
* Take Interstate 80 from Binghamton to Oneonta. * Follow Rte 23 East through Harpersfield, Stamford, Grand Gorge to Prattsville.